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CommunityReddit r/medicine·Jan 21, 2026

Question re: Newborn Vitamin K Administration Routes : IM vs SQ

By <name>/u/SectorRecent6916</name><uri>https://old.reddit.com/user/SectorRecent6916</uri>

Question came up today in a prenatal visit while discussing vitamin K for newborn after delivery. FoB stated that manufacturer information recommends subcutaneous administration over IM for routine prophylaxis. I have to say I'd never heard this before--frankly, I have never read the manufacturer information as IM administration is recommended by all the big organizations, is the routine way giving it, and is effective with low incident of reactions. So, I looked it up and Pfizer's information does indeed say exactly this: "Warning: Hypersensitivity Reactions with Intravenous and Intramuscular Use Fatal hypersensitivity reactions, including anaphylaxis, have occurred during and immediately after intravenous and intramuscular injection of Vitamin K1 Injection. Reactions have occurred despite dilution to avoid rapid intravenous infusion and upon first dose. Avoid the intravenous and intramuscular routes of administration unless the subcutaneous route is not feasible and the serious risk is justified [see Warnings and Precautions (5.1) ]." Here is the document link: Vitamin K1 _____ Can anyone offer an explanation as to why we all give vitamin K IM instead of SQ as the manufacturer recommends? or how this came to be the practice? submitted by /u/SectorRecent6916 [link] [comments]

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