ACC 2026 Late Breaker Guide
By <name>/u/MilkHopeful8966</name><uri>https://old.reddit.com/user/MilkHopeful8966</uri>
Here is my guide to ACC26 late breakers coming out this weekend Highest priority CHAMPION-AF = Left atrial appendage closure vs oral anticoagulation in atrial fibrillation (big population; likely guideline-relevant if clearly positive) VESALIUS-CV = Evolocumab in patients without significant atherosclerosis (very large prevention population; potentially major implications if compelling) Intensive LDL-C Targeting in ASCVD = More aggressive LDL cholesterol lowering in patients with established ASCVD (big population; highly likely to influence guideline discussion) β-blocker discontinuation after MI = Stopping beta-blocker therapy in stabilized patients after acute myocardial infarction (big population; likely guideline-relevant if definitive) HI-PEITHO = Ultrasound-facilitated catheter-directed thrombolysis vs anticoagulation alone for acute intermediate-high-risk pulmonary embolism (high-acuity management question; real practice-change potential) Interventional / structural STEMI-Door to Unload = Primary left ventricular unloading in anterior STEMI without cardiogenic shock (major interventional question) CHIP-BCIS3 = High-risk coronary intervention with percutaneous left ventricular unloading (important CHIP subgroup question) Angiography-derived physiology vs pressure wire PCI guidance = Using coronary physiology derived from angiography instead of invasive pressure wire guidance for PCI decisions (could matter for PCI workflow if clearly positive) ORBITA-CTO = Placebo-controlled trial of CTO PCI in stable angina (high controversy value; likely one of the most debated) FAST III = Vessel-FFR/3D quantitative angiography-guided revascularization vs standard FFR-type invasive guidance (relevant cath-lab workflow question) TAVI without routine PCI = TAVI strategy without routine coronary PCI (meaningful structural practice question) Protect The Head To Head = Emboliner vs Sentinel cerebral embolic protection during TAVR (important device-strategy comparison) OPTIMAL = I
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